pharmacology

头孢他啶-阿维巴坦

Ceftazidime-Avibactam

A novel β-lactam/β-lactamase inhibitor combination antibiotic used to treat infections caused by multidrug-resistant Gram-negative bacteria. / 一种新型β-内酰胺酶抑制剂复合抗生素，用于治疗多重耐药革兰氏阴性菌引起的感染。

Knowledge type: 实际应用
First proposed or discovered
Proposer: Turkey Farm member
Creator: 农场主
Last updated: 2026-10-24 23:00:54

Sub-knowledge points

Ceftazidime: Third-generation cephalosporinAvibactam: Non-β-lactam diazabicyclooctane (DBO) inhibitor

Higher-order knowledge points

Carbapenem Resistance / 自然理论Gram-negative bacterial infectionsAntibiotic stewardship

Main parameters and performance indicators

Mechanism: Inhibits class A, C, and some class D serine β-lactamasesSpectrum: Active against carbapenemase-producing Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumanniiIndication: Diabetic foot infections, pneumonia, bloodstream infections

Open problems

Emergence of resistance mechanismsOptimal dosing regimens for severe infectionsPharmacokinetic variability in specific patient populations

Related literature

ranked by community stars

Effect of Ceftazidime-Avibactam on Carbapenemase Producing Gram-Negative Bacteria Isolated from Patients with Diabetic Foot InfectionOpen source

头孢他啶-阿维巴坦

Sub-knowledge points

Higher-order knowledge points

Main parameters and performance indicators

Open problems

Related products and links