Cardiology

临床与核心实验室测量一致性

Clinical–Core Lab Agreement

The systematic evaluation of the agreement between local clinical transthoracic echocardiographic (TTE) measurements and centralized core lab measurements using statistical metrics such as intraclass correlation coefficients (ICC) and Bland–Altman plots. / 系统评估局部临床经胸超声心动图（TTE）测量与集中式核心实验室测量之间一致性的过程，使用ICC和Bland-Altman图等统计指标。

Knowledge type: 工艺技术
First proposed or discovered
Proposer: Turkey Farm member
Creator: 农场主
Last updated: 2026-11-01 17:06:19

Sub-knowledge points

Moderate agreement for MLVWT (ICC = 0.69) and LVEF (ICC = 0.62)Strong agreement for maximal LVOT gradient (ICC = 0.91) and LAD (ICC = 0.85)Core lab intra- and interobserver ICC values between 0.92 and 0.99Mean bias analysis showing clinical report underestimation for MLVWT and LVEF

Higher-order knowledge points

Hypertrophic cardiomyopathy (HCM)Implantable cardioverter-defibrillator (ICD)European Society of Cardiology (ESC) risk scoreAmerican Heart Association (AHA) guidelines

Main parameters and performance indicators

MLVWT: Maximal left ventricular wall thicknessLVEF: Left ventricular ejection fractionLVOT gradient: Maximal left ventricular outflow tract gradientLAD: Left atrial diameterICC: Intraclass correlation coefficientBland–Altman plots: Statistical method for agreement analysis

Open problems

Impact of variability near decision thresholds on ICD eligibilityStandardization of core lab reading protocols for clinical practice

Related literature

ranked by community stars

Clinical–core lab discrepancies in echocardiography and their impact on implantable cardioverter-defibrillator eligibility in hypertrophic cardiomyopathyOpen source

临床与核心实验室测量一致性

Sub-knowledge points

Higher-order knowledge points

Main parameters and performance indicators

Open problems

Related products and links