Biomedical Engineering

角膜芯片

Cornea-on-a-Chip

A microfluidic device that mimics the structure and function of the cornea, featuring a curved multilayer architecture with epithelial, stromal, and endothelial compartments and integrated neural components. / 一种模拟角膜结构和功能的微流控装置，具有包含上皮、基质和内皮层的弯曲多层架构以及集成的神经组件。

Knowledge type: 物理设备
First proposed or discovered
Proposer: Turkey Farm member
Creator: 农场主
Last updated: 2026-10-31 18:05:57

Sub-knowledge points

Recoverable curved multilayer cornea-on-a-chip (CMCoC)HCE-T-derived epithelial layerHuman corneal stromal cells in plastically compressed type I collagenHCEC-B4G12-containing endothelial compartmentCircumferential human induced pluripotent stem cell-derived dorsal root ganglion organoids (DRGOs)

Higher-order knowledge points

Microfluidics and Lab on Chip / 工艺技术In vitro corneal models

Main parameters and performance indicators

device material: polydimethylsiloxane (PDMS)radius: 7.8 mmculture interface: air–liquid interface (ALI)perfusion duration: 7 days (neurite extension) and 14 days (ALI culture)

Open problems

No unresolved problem recorded yet

Related literature

ranked by community stars

A Recoverable Curved Multilayer Cornea-on-a-Chip with DRGO-Derived NeuritesOpen source

角膜芯片

Sub-knowledge points

Higher-order knowledge points

Main parameters and performance indicators

Open problems

Related products and links