Biological Sciences
铜死亡
CuproptosisA novel form of regulated cell death characterized by the accumulation of copper ions and the targeting of lipoylated proteins by the electron transport chain complex I. / 一种新型的程序性细胞死亡形式，其特征是铜离子的积累以及电子传递链复合物I对脂酰化蛋白的靶向。
- Knowledge type
- 自然理论
- First proposed or discovered
- 2021
- Proposer
- Tsvetan P. Bagci
- Creator
- 农场主
- Last updated
- 2026-10-27 20:01:29
Sub-knowledge points
Mitochondrial toxicityProtein aggregation
Higher-order knowledge points
Regulated cell death pathwaysMetal ion biology
Main parameters and performance indicators
Cu+: Copper ion concentrationLipoylated proteins: Target substratesComplex I: Electron transport chain component
Open problems
Therapeutic targeting mechanismsSpecificity in vivo
Related literature
ranked by community starsA novel tumor-anchored fluorescent probe for imaging HClO in cuproptosis and pyroptosis modelsOpen source
Related products and links
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Creation and modification trail
1 recordsRecord title: Cuproptosis.
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