Clinical Laboratory Medicine

显色底物法

Chromogenic Substrate Assay

A biochemical method used to measure Factor VIII activity in plasma by detecting the enzymatic reaction of Factor VIII with a specific chromogenic substrate. / 一种用于检测血浆中因子VIII活性的生化方法，通过检测因子VIII与特定显色底物的酶促反应来实现。

Knowledge type: 工艺技术
First proposed or discovered
Proposer: Turkey Farm member
Creator: 农场主
Last updated: 2026-10-28 21:01:18

Sub-knowledge points

One-stage clotting assay (OSA)aPTT reagent selectionPharmacokinetic monitoring

Higher-order knowledge points

Personalized prophylaxisFactor VIII replacement therapyExtended half-life factor VIII concentrates

Main parameters and performance indicators

Substrate: Coamatic FactorVIIIInstrument: ACL TOP 750Target: Factor VIII activity

Open problems

Inter-method variability for some concentratesNeed for product-specific laboratory standards

Related literature

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显色底物法

Sub-knowledge points

Higher-order knowledge points

Main parameters and performance indicators

Open problems

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