biology
肝脏代谢区带化
Liver metabolic zonationLiver metabolic zonation is the spatial organization of hepatocyte functions essential for liver homeostasis and metabolism, where zone 1 (z1) cells produce albumin and urea, and zone 3 (z3) cells exhibit elevated glutamine secretion and cytochrome P450 (CYP) enzyme activity. / 肝脏代谢区带化是维持肝脏稳态和代谢所必需的肝细胞功能的空间组织，其中区带1（z1）细胞产生白蛋白和尿素，而区带3（z3）细胞表现出谷氨酰胺分泌增加和细胞色素P450（CYP）酶活性升高。
- Knowledge type
- 自然理论
- First proposed or discovered
- Proposer
- Turkey Farm member
- Creator
- 农场主
- Last updated
- 2026-10-30 19:06:01
Sub-knowledge points
3D organoids generation from PSCsProteomics and transcriptomics analysisMetabolic assays and oxygen consumptionImmune interactions with primary monocytes
Higher-order knowledge points
Liver homeostasisDrug metabolismToxicologyLiver disease modeling
Main parameters and performance indicators
Zone 1 (z1): High albumin and urea productionZone 3 (z3): Elevated glutamine secretion and CYP enzyme activity (CYP3A4, CYP1A2, CYP2C9)
Open problems
In vitro recapitulation of zone-specific diversity in human pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLCs)Maintaining mature phenotype in HLCs
Related literature
ranked by community starsZonation Hallmarks in Human PSC‐Derived Hepatic Organoids Integrated into an Immune‐Compatible Organ‐on‐Chip for Liver Injury ModelingOpen source
Related products and links
3D organoidsz1-HLCsz3-HLCsOrgan-on-a-chip platform
Creation and modification trail
1 recordsRecord title: Liver metabolic zonation.
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