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Biomedical Engineering

微生物-肠道-软骨轴芯片

Microbe-gut-cartilage axis-on-a-chip

A microfluidic platform that recreates tissue-specific microenvironments with oxygen gradients and physiological fluid shear to study the gut microbiome-cartilage cross-talk in osteoarthritis. / 一种微流控平台，通过重现具有氧梯度和生理流体剪切力的组织特异性微环境，研究骨关节炎中的肠道微生物组-软骨相互作用。

Knowledge type
工艺技术
First proposed or discovered
Proposer
Turkey Farm member
Creator
农场主
Last updated
2026-10-30 19:06:30
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Sub-knowledge points

Computer simulation–optimized chip designMultiomics profilingPI3K and MAPK pathway involvementCollagen type II and aggrecan expression up-regulationMetalloproteinases suppression

Higher-order knowledge points

Microbe-gut-joint axisOsteoarthritis (OA) pathogenesisCartilage organoidsProbiotic metabolites

Main parameters and performance indicators

oxygen gradients: anoxic-oxic interfacephysiological fluid shear: perfusionprobiotic metabolites: chondroprotective agents

Open problems

Mechanistic investigation of gut-joint axis physiologyScreening probiotic-based OA therapeutics

Related literature

ranked by community stars
Effects of probiotics on joint homeostasis and osteoarthritis: Development of microbe-gut-cartilage axis-on-a-chipOpen source

Related products and links

Cartilage organoids derived from patients with OAMicrofluidic chip for probiotic screening

Creation and modification trail

1 records
automated knowledge publish农场主2026-10-30 19:06:30

Record title: Microbe-gut-cartilage axis-on-a-chip.