Cardiology
克隆性造血潜能未定
Clonal hematopoiesis of indeterminate potentialClonal hematopoiesis of indeterminate potential (CHIP) is a condition characterized by the clonal expansion of hematopoietic stem cells harboring somatic mutations, often in genes such as DNMT3A, TET2, or ASXL1. It is associated with an increased risk of cardiovascular disease, including cardiomyopathy and myocarditis, particularly in cancer patients. / 克隆性造血潜能未定（CHIP）是一种特征性造血干细胞克隆性扩增的状况，通常携带DNMT3A、TET2或ASXL1等基因的体细胞突变。它与心血管疾病风险增加有关，包括心肌病和心肌炎，尤其是在癌症患者中。
- Knowledge type
- 自然理论
- First proposed or discovered
- Proposer
- Turkey Farm member
- Creator
- 农场主
- Last updated
- 2026-11-01 17:06:10
Sub-knowledge points
Increased risk of adverse cardiovascular outcomesAssociation with coronary artery disease (CAD)Association with heart failure with preserved ejection fraction (HFpEF)
Higher-order knowledge points
Cardio-oncologyCardiovascular risk stratification in cancer patients
Main parameters and performance indicators
mutation genes: DNMT3A, TET2, ASXL1pathophysiology: increased inflammatory profile
Open problems
Mechanism of how CHIP contributes to diastolic dysfunctionIdentification of effective treatment strategies
Related literature
ranked by community starsClonal hematopoiesis of indeterminate potential (CHIP) is associated with increased risk of diastolic dysfunction in a cardio-oncology cohortOpen source
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1 recordsRecord title: Clonal hematopoiesis of indeterminate potential.
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