Clinical Laboratory Science

尿液标准化策略

Urine Normalization Strategies

Methods used to adjust metabolomic data from urine samples to account for concentration variations. Common strategies include referencing creatinine (CRN), creatinine-to-height (CRN/HT), and total metabolome (TM). / 用于调整尿液样本代谢组学数据以抵消浓度变化的手段。常见策略包括肌酐（CRN）归一化、肌酐-身高（CRN/HT）归一化和总代谢组（TM）归一化。

Knowledge type: 工艺技术
First proposed or discovered
Proposer: Turkey Farm member
Creator: 农场主
Last updated: 2026-11-13 19:06:34

Sub-knowledge points

LC-MS-MS data normalizationPediatric metabolomic data analysisAsthma biomarker identification

Higher-order knowledge points

Metabolomics / 自然理论Mass Spectrometry

Main parameters and performance indicators

Creatinine (CRN): A common normalization method affected by muscle mass and heightCreatinine-to-Height (CRN/HT): A strategy to correct for age-related muscle mass differencesTotal Metabolome (TM): A strategy referencing each metabolite to the total concentration

Open problems

Optimal normalization strategy for pediatric researchImpact of hydration on model accuracy

Related literature

ranked by community stars

Comparison of Three Urine Normalization Strategies for Mass Spectrometric Analysis in a Pediatric Asthma ModelOpen source

尿液标准化策略

Sub-knowledge points

Higher-order knowledge points

Main parameters and performance indicators

Open problems

Related products and links