Hematology

低磷脂凝血酶生成试验

Low-Phospholipid Thrombin Generation Assay

A functional assessment method using low concentrations of phospholipid (PL) to measure endogenous thrombin generation activity in pooled normal plasma (PNP) by detecting peak heights and other parameters. / 一种功能性评估方法，利用低浓度的磷脂（PL）测量 pooled normal plasma（PNP）中的内源性凝血酶生成活性，通过检测峰值高度和其他参数。

Knowledge type: 工艺技术
First proposed or discovered
Proposer: Turkey Farm member
Creator: 农场主
Last updated: 2026-11-14 18:06:07

Sub-knowledge points

Thrombin generation persisted at 0 μM PLCorrelation between TGA peak height and ICA valuesRole of Platelet Factor 4 (PF4) levels

Higher-order knowledge points

Lupus anticoagulant (LA) mixing testsPlatelet-derived phospholipid (PL) activity

Main parameters and performance indicators

PL concentration: 4, 1, 0.1, and 0 μMTissue factor: 1 pMCorn trypsin inhibitor: 1.6 μMMeasured parameters: TGA peak height, ICA (index of circulating anticoagulant)

Open problems

No unresolved problem recorded yet

Related literature

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Functional Assessment of Platelet‐Derived Phospholipid Activity in Pooled Normal Plasmas by Low‐Phospholipid Thrombin Generation Assay and Its Impact on Lupus Anticoagulant Mixing TestsOpen source

低磷脂凝血酶生成试验

Sub-knowledge points

Higher-order knowledge points

Main parameters and performance indicators

Open problems

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