Bioengineering
微生理系统
Microphysiological SystemsMicrophysiological systems (MPSs) are engineered platforms that mimic the structure and function of human tissues to study the interaction of chemicals, nanoparticles, and circulating cells with the endothelium under controlled mechanical shear conditions. / 微生理系统（MPSs）是一种工程化平台，旨在模拟人体组织的结构和功能，以研究在受控机械剪切条件下，化学物质、纳米颗粒和循环细胞与内皮的相互作用。
- Knowledge type
- 实际应用
- First proposed or discovered
- Proposer
- Turkey Farm member
- Creator
- 农场主
- Last updated
- 2026-11-13 19:06:20
Sub-knowledge points
Endothelial cell cultureBarrier tissue function simulationMathematical modeling for operating parametersImmunostaining of adherens junction protein (VE-cadherin) and actin filaments
Higher-order knowledge points
Main parameters and performance indicators
Shear stress magnitude: Critical for endothelial health and barrier functionFlow direction: Unidirectional mimics healthy conditions, bidirectional mimics diseaseRecirculation volume: Adjustable range from 100 µL to 5 mLFlow rate: Wide range to accommodate low shear (interstitial) and high shear (blood flow) conditions
Open problems
Achieving medium recirculation of small volumes with precise flow control in existing designsReproducing specific shear conditions faithfully in MPSInvestigating expensive compounds limited to very small volume samples
Related literature
ranked by community starsVersatile Microfluidic System for Creating Recirculating Unidirectional Flow for On-Chip Cultures of Barrier TissuesOpen source
Related products and links
Versatile Microfluidic SystemOn-chip cultures of barrier tissues
Creation and modification trail
1 recordsRecord title: Microphysiological Systems.
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