Virology
病毒复制细胞器
Viral Replication OrganelleMembranous structures formed by positive-strand RNA viruses within host cells to facilitate viral replication. They are dynamic condensates driven by viral replication proteins and co-opted host factors. / 正链RNA病毒在宿主细胞内形成的膜结构，用于促进病毒复制。它们是由病毒复制蛋白和共宿主因子驱动的动态凝聚体。
- Knowledge type
- 自然理论
- First proposed or discovered
- Proposer
- Turkey Farm member
- Creator
- 农场主
- Last updated
- 2026-10-29 20:06:17
Sub-knowledge points
Membranous VROsvir-condensate substructuresCo-opted glycolytic enzymesProtein aggregation control
Higher-order knowledge points
Positive-strand RNA virus replicationHost-pathogen interactionProtein quality control
Main parameters and performance indicators
VROs: Viral Replication OrganellesTBSV: Tomato bushy stunt virusp33: TBSV replication proteinCHIP/STUB1: Co-opted E3 ubiquitin ligase
Open problems
Mechanism of dynamic maintenance of vir-condensatesSpecific regulation of protein interactions by subverted CHIP
Related literature
ranked by community starsCo-opted CHIP E3 Ub-ligase provides protein quality control by regulating molecular properties of condensates formed by a positive-strand RNA virusOpen source
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Creation and modification trail
1 recordsRecord title: Viral Replication Organelle.
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